The Laboratory of Chemical Epigenetics
The Laboratory of Chemical Epigenetics
March, 2017
Congratulations Dr. Xiang David Li on winning Outstanding Young Researcher Award!

December, 2016
Our research paper entitled “Histone Ketoamide Adduction by 4-Oxo-2-nonenal Is a Reversible Posttranslational Modification Regulated by Sirt2” was published in ACS Chemical Biology. 
Posttranslational modifications (PTMs, e.g. acetylation, phosphorylation, methylation, lipidation) of proteins are involved in the regulation of essentially every cellular process, such as gene expression, signal transduction and metabolism. The LI group is interested in studying regulatory mechanisms and cellular functions of PTMs by combining state-of-the-art chemistry, biochemistry, biophysics and cell biology approaches.
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